Endocrine Abstracts

Introduction: Brown tumors are rare focal giant-cell lesions that arise as a direct result of the effect of parathyroid hormone on bone tissue in some patients with hyperparathyroidism.Case: A 55-year-old Saudi woman was admitted to King Abdulaziz University Hospital (Jeddah) with a complaint of anterior maxilla mass of one month duration. Her medical history was unremarkable.Initial examination revealed a painful mass in the anter...

Background and objectives: Certain diseases, such as multiple endocrine neoplasia type 2A (MEN2A), MEN2B, familial and sporadic medullary thyroid carcinoma (MTC) and renal dysgenesis are related to abnormalities of the RET protein. Our aim was to evaluate the frequency of RET mutation in ten Saudi families with MEN2A and familial medullary thyroid carcinoma.Design and setting: Cross-sectional prospective study of patients followed up at King Abd...

Objective: The objective of this study was to investigate the correlation between the neurological manifestations of Vitamin D deficiency and the levels of 25(OH) D and bone profile.Methods: We conducted a case series study in patients with osteomalacia who were followed up at King Abdulaziz Medical City, Jeddah, between January 2010 and December 2011. We collected information on demographic data, etiological factors for Vitamin D deficiency, clinical pr...

A 53 year-old woman presented with labile and difficult to control hypertension on three deferent anti hypertensive medications. Abdominal computed tomography (CT) and Ultrasonography of the thyroid gland showed 1.8 cm thyroid nodule. Fine needle aspiration biopsy of the thyroid nodule revealed papillary thyroid carcinoma. Serum TSH & FT4, calcitonin, CEA, intact PTH and calcium levels were within normal limits. A 24-h urine metanephrines showed significant elev...

Objective: To evaluate pheochromocytoma that occurs in Saudi patients with MEN 2APatients and methods: Of 44 patients belonging to 5 MEN 2A families, 14 (31.8%) presented with pheochromocytoma. The following variables have been studied: clinical and diagnostic data (age, mutation, clinical features, and laboratory studies included measurements of 24-h urinary catecholamines, epinephrine, metanephrine, norepinephrine, dopamine, vanillylmandelic acid, and ...

A 47-year-old, previously healthy, ex-smoker male presented with a two-week history of dyspnea grade 4 with progressive course, palpitations, orthopnea, and paroxysmal nocturnal dyspnea. There was no history of chest pain or fever, but he had noticed recent an unintentional 10 to 15 kg weight loss over the previous 3 months. There was no previous history of cardiorespiratory problems, hypertension, and diabetes. On examination he was dyspenic, anxious and tremulous. His temper...

Objective: To evaluate the prevalence of the RET mutation and the genotype–phenotype relation in Saudi patients (families) with multiple endocrine neoplasia type 2A (MEN2A) or familial medullary thyroid carcinoma (FMTC).Design: Cross-sectional study.Patients and methods: A total of ten unrelated Saudi families with germline mutation of the RET protooncogene and/or immunohistochemistry diagnosis of MTC were identified. B...